Title :
Computer modelling of a glucose-sensitive membrane device
Author :
Klumb, Lisa A. ; Horbett, Thomas A.
Author_Institution :
Dept. of Chem. Eng., Washington Univ., Seattle, WA, USA
Abstract :
A computer model of a glucose-sensitive membrane device that includes an additional flux of oxygen from the insulin reservoir to alleviate the oxygen depletion problem has been developed. The response of the membrane with the additional flux of oxygen shows a larger pH drop and a greater sensitivity to glucose than in the case where there is no flux of oxygen from the insulin reservoir. The sensitivity to glucose is shown to increase to 200 mg% glucose as compared to the no-flux limit of 100 mg% with the pH drop increasing as well
Keywords :
biomedical equipment; biomedical measurement; biosensors; chemical variables measurement; medical computing; membranes; pH; O2; computer model; glucose-sensitive membrane device; insulin reservoir; oxygen depletion problem; pH drop; sensitivity; Biomedical engineering; Biomembranes; Chemical engineering; Electrostatics; Insulin; Ionization; Permeability; Production; Reservoirs; Sugar;
Conference_Titel :
Engineering in Medicine and Biology Society, 1989. Images of the Twenty-First Century., Proceedings of the Annual International Conference of the IEEE Engineering in
Conference_Location :
Seattle, WA
DOI :
10.1109/IEMBS.1989.96104
