Title :
3D MEMS based minimally invasive optical coherence tomography
Author :
McCormick, Daniel T. ; Jung, Woonggyu ; Chen, Zhongping ; Tien, Norman C.
Author_Institution :
Dept. of Electr. Eng. & Comput. Sci., California Univ., Berkeley, CA, USA
Abstract :
A 3D optical coherence tomography (OCT) system based on a high-speed micromachined scanning mirror is presented. The sampling resolution of each voxel is 10μm×10μm×10μm the optical resolution is 20μm×20μm×10μm. In this work test-structures as well as in-vitro and in-vivo biological tissue samples are imaged. Cross-sectional images are collected and displayed in realtime; these images are subsequently combined to reconstruct a 3D image of the sample. Images from the 3D MEMS OCT system have been utilized to clearly identify dysplasia (initial stage of cancer) in hamster cheek pouch tissue by experts in the field, and have shown excellent correlation with histology slides of the same sample.
Keywords :
biological tissues; biomedical optical imaging; image reconstruction; medical image processing; micromechanical devices; micromirrors; optical tomography; 3D MEMS OCT system; 3D image reconstruction; 3D optical coherence tomography system; bio-photonics; dysplasia; high-speed micromachined scanning mirror; in-vitro biological tissues; in-vivo biological tissues; optical microelectromechanical systems; Biological tissues; Biomedical optical imaging; High speed optical techniques; Image sampling; In vitro; Micromechanical devices; Minimally invasive surgery; Mirrors; Testing; Tomography;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. TRANSDUCERS '05. The 13th International Conference on
Print_ISBN :
0-7803-8994-8
DOI :
10.1109/SENSOR.2005.1497404
