Title :
A MEMS viscometric glucose monitoring device
Author :
Zhao, Y.J. ; Davidson, A. ; Bain, J. ; Li, S.Q. ; Wang, Q. ; Lin, Q.
Author_Institution :
Dept. of Mech. Eng., Carnegie Mellon Univ., Pittsburgh, PA, USA
Abstract :
We report a MEMS device for continuously monitoring glucose levels in diabetics. The device features a micro-cantilever and a semi-permeable membrane, which are integrated with micro-channels forming a miniature device chamber with a volume of 0.4 μl. The sensor is based on affinity binding principles using the Dextran/Con-A system. The glucose concentration is determined by detecting viscosity changes induced by binding of glucose with Con-A through measurement of the cantilever´s vibration parameters. The device is capable of measuring physiologically relevant glucose concentrations from 0 to 25 mM with a resolution better than 0.02 mM. The time for the system to reach binding equilibrium is less than 5 minutes in response to changes in glucose concentration.
Keywords :
biomedical equipment; chemical sensors; diseases; microsensors; patient monitoring; sugar; viscosity measurement; Dextran/Con-A system; MEMS device; MEMS viscometric glucose monitoring device; affinity binding principles; binding equilibrium; biosensors; cantilever vibration parameters; continuous glucose monitoring; diabetes; diabetics; glucose level monitoring; microcantilever; microchannels; miniature device chamber; physiologically relevant glucose concentrations; semipermeable membrane; viscosity change detection; Biomembranes; Biosensors; Computerized monitoring; Diabetes; Microelectromechanical devices; Micromechanical devices; Sensor systems; Sugar; Vibration measurement; Viscosity;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. TRANSDUCERS '05. The 13th International Conference on
Print_ISBN :
0-7803-8994-8
DOI :
10.1109/SENSOR.2005.1497447
