Acoustic plate-wave biosensing

Author

Costello, Benedict J. ; Martin, Bret A. ; White, Richard M.

Author_Institution

California Univ., Berkeley, CA, USA

fYear

1989

fDate

9-12 Nov 1989

Firstpage

1108

Abstract

The biosensing potential of a flexural plate-wave delay-line oscillator is described. Experimental results confirm theoretical predictions that the sensor can operate in contact with a liquid and still detect small changes in membrane mass. A response to adsorbed proteins is observed as a prelude to the detection of specific biomolecular reactions and implies that the sensor can be used to monitor specific biomolecular reactions. The delay-line oscillator also provides a tool for monitoring adsorption of molecules at each step of a covalent immobilization process in real time

Keywords

biological techniques and instruments; biosensors; membranes; molecular biophysics; ultrasonic delay lines; acoustic plate wave biosensing; adsorbed proteins; biomolecular reactions; covalent immobilization process; flexural plate-wave delay-line oscillator; liquid contact; membrane mass; molecule adsorption monitoring; real time; Acoustic sensors; Acoustic waves; Biomembranes; Biosensors; Chemical and biological sensors; Copper; Frequency; Ice thickness; Oscillators; Silicon;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1989. Images of the Twenty-First Century., Proceedings of the Annual International Conference of the IEEE Engineering in

Conference_Location

Seattle, WA

Type

conf

DOI

10.1109/IEMBS.1989.96109

Filename

96109