A KTAP framework for anylyzing cellular self-repair kinetics under external stress

Author

Qi, Jinpeng ; Ding, Yongsheng ; Wu, Yizhi ; Zhu, Ying

Author_Institution

Coll. of Inf. Sci. & Technol., Donghua Univ., Shanghai, China

fYear

2011

fDate

15-18 May 2011

Firstpage

743

Lastpage

748

Abstract

To analyze different kinetics of cellular responding genome stress under external perturbation circumstances, a mathematical model of cellular self-repair process is proposed by using the Kinetic Theory of Active Particles (KTAP) framework. Under continuous function of ion radiation (IR), the processes of DNA damage and Repair Protein (RP) generation, DSBC syntheses, and cellular toxins accumulation are represented by the particle interactions between the pairs of active molecules within different two sub-systems. Especially, the capability of cellular self-repair mechanisms, cellular activity and genome stability in response to genome stress are analyzed under different IR dose domains.

Keywords

DNA; biochemistry; biological effects of ionising particles; biomechanics; cellular effects of radiation; genomics; molecular biophysics; proteins; DNA damage; KTAP Framework; Kinetic Theory of Active Particles framework; cellular self-repair kinetics; cellular toxin accumulation; genome stability; genome stress effect; ion radiation dose domains; mathematical model; particle interactions; repair protein generation; Bioinformatics; DNA; Genomics; Kinetic theory; Maintenance engineering; Proteins; Stress; Genome Stress; KTAP; Modelling; Perturbation;

fLanguage

English

Publisher

ieee

Conference_Titel

Control Conference (ASCC), 2011 8th Asian

Conference_Location

Kaohsiung

Print_ISBN

978-1-61284-487-9

Electronic_ISBN

978-89-956056-4-6

Type

conf

Filename

5899164