Title :
Ion accumulation and arrhythmogenesis in networks of cardiac cells
Author :
Varghese, Anthony ; Winslow, Raimond L.
Author_Institution :
Johns Hopkins Med. Sch., Baltimore, MD, USA
Abstract :
The authors examine the effects of Na-K pump blockade in cardiac atrial tissue using mathematical modeling and analysis. A complex model of electrochemical activity in atrial cells comprising a system of 17 differential equations are analysed to predict the occurrence of oscillatory calcium dynamics. Spatial patterns of ion accumulation were investigated in networks of cardiac cells coupled by gap junctions where a small part of the network was subjected to Na-K pump poisoning. Simulations were performed on workstations and the results were then used to set up initial conditions of computations of the full cell network model on a parallel supercomputer.<>
Keywords :
bioelectric phenomena; biology computing; biomembrane transport; cardiology; differential equations; electrochemistry; physiological models; Ca; K; Na; Na-K pump blockade effect; Na-K pump poisoning; arrhythmogenesis; cardiac atrial tissue; cardiac cells networks; complex model; computation initial conditions; differential equations system; electrochemical activity; gap junctions; ion accumulation; mathematical modeling; oscillatory calcium dynamics; parallel supercomputer; spatial patterns; Calcium; Computational modeling; Computer networks; Concurrent computing; Differential equations; Heart rate variability; Intelligent networks; Mathematical model; Rabbits; Workstations;
Conference_Titel :
Computers in Cardiology 1994
Conference_Location :
Bethesda, MD, USA
Print_ISBN :
0-8186-6570-X
DOI :
10.1109/CIC.1994.470161
