Title :
A 5–300MHz CMOS transceiver for multi-nuclear NMR spectroscopy
Author :
Kim, Jaehyup ; Hammer, Bruce ; Harjani, Ramesh
Author_Institution :
Univ. of Minnesota, Minneapolis, MN, USA
Abstract :
This paper presents a 5-300MHz multi-nuclei NMR transceiver designed with spectroscopy for drug discovery in mind. The overall transceiver (transmitter and receiver), is implemented in 130nm CMOS, occupies an active area of 2mm2 and consumes 12mA from a 1.5V supply. The measured phase noise for the on-chip frequency synthesizer is -110dBc at 10KHz offset when the LO frequency is 212.966MHz (~1H Larmor frequency at 5T). The measured input referred noise floor for the overall receiver is 3.5nV/√Hz. The receiver NMR functionality was validated using a variety of chemical samples, including adenosine triphosphaste(ATP), benzene(C6H6) and ethanol(CH3CH2OH) in a 5T magnet. Full transceiver NMR functionality, including that of of the internal power amplifier, was validated with the help of a 0.3mL H2O sample.
Keywords :
CMOS analogue integrated circuits; NMR spectroscopy; biomedical electronics; biomedical equipment; drug delivery systems; organic compounds; phase noise; power amplifiers; transceivers; 5T magnet; ATP; CMOS transceiver; LO frequency; Larmor frequency; adenosine triphosphaste; benzene; chemical samples; current 12 mA; drug discovery; ethanol; frequency 5 MHz to 300 MHz; internal power amplifier; measured input referred noise floor; multinuclear NMR spectroscopy; multinuclei NMR transceiver; on-chip frequency synthesizer; phase noise measurement; receiver NMR functionality; size 130 nm; transceiver NMR functionality; voltage 1.5 V; CMOS integrated circuits; Coils; Nuclear magnetic resonance; Phase noise; Receivers; Transceivers;
Conference_Titel :
Custom Integrated Circuits Conference (CICC), 2012 IEEE
Conference_Location :
San Jose, CA
Print_ISBN :
978-1-4673-1555-5
Electronic_ISBN :
0886-5930
DOI :
10.1109/CICC.2012.6330645
