A 5–300MHz CMOS transceiver for multi-nuclear NMR spectroscopy

Author

Kim, Jaehyup ; Hammer, Bruce ; Harjani, Ramesh

Author_Institution

Univ. of Minnesota, Minneapolis, MN, USA

fYear

2012

fDate

9-12 Sept. 2012

Firstpage

1

Lastpage

4

Abstract

This paper presents a 5-300MHz multi-nuclei NMR transceiver designed with spectroscopy for drug discovery in mind. The overall transceiver (transmitter and receiver), is implemented in 130nm CMOS, occupies an active area of 2mm² and consumes 12mA from a 1.5V supply. The measured phase noise for the on-chip frequency synthesizer is -110dBc at 10KHz offset when the LO frequency is 212.966MHz (~¹H Larmor frequency at 5T). The measured input referred noise floor for the overall receiver is 3.5nV/√Hz. The receiver NMR functionality was validated using a variety of chemical samples, including adenosine triphosphaste(ATP), benzene(C₆H₆) and ethanol(CH₃CH₂OH) in a 5T magnet. Full transceiver NMR functionality, including that of of the internal power amplifier, was validated with the help of a 0.3mL H₂O sample.

Keywords

CMOS analogue integrated circuits; NMR spectroscopy; biomedical electronics; biomedical equipment; drug delivery systems; organic compounds; phase noise; power amplifiers; transceivers; 5T magnet; ATP; CMOS transceiver; LO frequency; Larmor frequency; adenosine triphosphaste; benzene; chemical samples; current 12 mA; drug discovery; ethanol; frequency 5 MHz to 300 MHz; internal power amplifier; measured input referred noise floor; multinuclear NMR spectroscopy; multinuclei NMR transceiver; on-chip frequency synthesizer; phase noise measurement; receiver NMR functionality; size 130 nm; transceiver NMR functionality; voltage 1.5 V; CMOS integrated circuits; Coils; Nuclear magnetic resonance; Phase noise; Receivers; Transceivers;

fLanguage

English

Publisher

ieee

Conference_Titel

Custom Integrated Circuits Conference (CICC), 2012 IEEE

Conference_Location

San Jose, CA

ISSN

0886-5930

Print_ISBN

978-1-4673-1555-5

Electronic_ISBN

0886-5930

Type

conf

DOI

10.1109/CICC.2012.6330645

Filename

6330645