Title :
Multi-channel time-resolved tissue oximeter for functional imaging of the brain
Author :
Torricelli, Alessandro ; Pifferi, Antonio ; Spinelli, Lorenzo ; Taroni, Paola ; Quaresima, Valentina ; Ferrari, Marco ; Cubeddu, Rinaldo
Author_Institution :
INFM-Dipt. di Fisica, Politecnico di Milano, Milan, Italy
Abstract :
We report the development and characterization of a novel multichannel time-resolved instrument for functional brain imaging studies. The instrument is based on picosecond diode lasers, fiber optics for light injection and delivery, a compact multianode photomultiplier and a PC board for time-correlated single photon counting. The instrument has been characterized in term of reproducibility among the 9 sources and the 12 collection channels, linearity in the determination of optical properties (absorption and reduced scattering), and stability. Preliminary in vivo measurements were performed on volunteers to monitor the optical response to stimuli following motor (finger opposition, 5 Hz) or cognitive task (word generation).
Keywords :
biomedical equipment; biomedical optical imaging; brain; image reconstruction; infrared imaging; infrared spectroscopy; medical image processing; oximetry; photon counting; time resolved spectroscopy; PC board; cognitive task; compact multianode photomultiplier; fast image reconstruction; fiber optic light injection; finger opposition; functional brain imaging; in vivo measurements; motor task; multichannel time-resolved instrument; near infrared spectroscopy; optical response to stimuli; picosecond diode lasers; reproducibility; time-correlated single photon counting; time-resolved tissue oximeter; Absorption; Brain; Diode lasers; Instruments; Linearity; Optical fibers; Optical imaging; Optical scattering; Photomultipliers; Reproducibility of results;
Conference_Titel :
Instrumentation and Measurement Technology Conference, 2004. IMTC 04. Proceedings of the 21st IEEE
Print_ISBN :
0-7803-8248-X
DOI :
10.1109/IMTC.2004.1351475
