Title :
A model for nanomechanical behavior of microcantilever-ssDNA chip induced by electrostatic repulsion
Author :
Zhang, Neng-hui ; Shan, Jin-ying
Author_Institution :
Dept. of Mech., Shanghai Univ., Shanghai, China
Abstract :
The paper is devoted to study of the influence of screened electrostatic repulsion on nanomechanical behavior of microcantilever-DNA chip during the grafting process. First, Zhang´s two-variable method for laminated cantilevers and the sphere-chain model for single-stranded DNA (ssDNA) are combined to formulate a four-layered energy model for ssDNA chip systems. Second, the influence of grafting density, ssDNA chain length on immobilization deflection is investigated by the minimum principle of energy and the cell method in Monte Carlo (MC) simulation. Numerical predictive tendency at high salt concentration is similar to those observed in some related experiments on ssDNA chips.
Keywords :
DNA; Monte Carlo methods; bioMEMS; cantilevers; electrostatics; lab-on-a-chip; laminates; Monte Carlo simulation; Zhang two-variable method; four-layered energy model; grafting process; immobilization deflection; laminated cantilevers; microcantilever-ssDNA chip; screened electrostatic repulsion; single-stranded DNA; sphere-chain model; ssDNA chain length; Biosensors; DNA; Electrostatics; Gold; Mathematical model; Monte Carlo methods; Optical buffering; Predictive models; Sensor arrays; Tensile stress; Monte Carlo simulation; Single-stranded DNA; electrostatic repulsive; microcantilever chip; nanomechanical deflection;
Conference_Titel :
Piezoelectricity, Acoustic Waves, and Device Applications (SPAWDA) and 2009 China Symposium on Frequency Control Technology, Joint Conference of the 2009 Symposium on
Conference_Location :
Wuhan
Print_ISBN :
978-1-4244-4950-7
DOI :
10.1109/SPAWDA.2009.5428987
