Design of a novel constant current pulsed iontophoretic stimulation device

Author

Zakzewski, Christine A. ; Li, John K-J ; Amory, David W. ; Kalatzis-Manolakis, Elizabeth

Author_Institution

Dept. of Biomed. Eng., Rutgers Univ., Piscataway, NJ, USA

fYear

1992

fDate

1992

Firstpage

33

Lastpage

34

Abstract

An instrument for constant current iontophoretic transdermal drug delivery was designed, prototyped, and preliminarily tested in the New Zealand white rabbit. This flexible device has been designed to synthesize several constant current output waveshapes of selectable magnitude, frequency, and duty cycle. The output waveforms include the conventional DC and monophasic pulsed DC, as well as two novel iontophoretic waveforms-a trapezoidal and a symmetrical biphasic pulsed DC. Each waveform was used to deliver an angiotensin-converting enzyme inhibitor transdermally to a rabbit with induced hypertension to compare relative antihypertensive efficacy.

Keywords

bioelectric phenomena; biomedical equipment; electrophoresis; patient treatment; New Zealand white rabbit; angiotensin-converting enzyme inhibitor; antihypertensive efficacy; constant current pulsed iontophoretic stimulation device; conventional DC; duty cycle; monophasic pulsed DC; Biomedical engineering; Capacitance; Drug delivery; Frequency; Immune system; Optical pulses; Polarization; Prototypes; Rabbits; Skin;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 1992., Proceedings of the 1992 Eighteenth IEEE Annual Northeast

Conference_Location

Kingston, RI, USA

Print_ISBN

0-7803-0902-2

Type

conf

DOI

10.1109/NEBC.1992.285925

Filename

285925