Medical diagnostics using digitized optical imaging

Author

Benner, Robert E.

Author_Institution

Dept. of Electr. Eng., Utah Univ., Salt Lake City, UT, USA

fYear

1989

fDate

9-12 Nov 1989

Firstpage

1205

Abstract

An electronic optical imaging system consisting of a computer-controlled CCD array with 576×384 detection elements and 14 bits of digitization is presented. The system is used for in-vivo characterization of laser-tissue interactions by obtaining spatially resolved transmission images as a function of wavelength with a resolution on the order of 10 μm from tissue structure using the hamster flap model. Fluorescence images of the hamster tissue excited with argon laser light at 457.9 nm before and as a function of time after injection of the photosensitizing drug Photofrin II are described, The system is also used to obtain internal and external intensity distributions for optical fiber tips proposed for use with photodynamic therapy and laser angioplasty

Keywords

biomedical measurement; computerised picture processing; fluorescence; laser applications in medicine; patient diagnosis; 457.9 nm; Ar laser light; computer-controlled CCD array; digitized optical imaging; electronic optical imaging system; fluorescent images; hamster flap model; hamster tissue; in-vivo characterization; laser angioplasty; laser-tissue interactions; medical diagnostics; optical fiber tips; photodynamic therapy; photosensitizing drug Photofrin II; resolution; spatially resolved transmission images; wavelength; Charge coupled devices; Fiber lasers; Fluorescence; Image resolution; Laser modes; Medical diagnosis; Optical arrays; Optical computing; Optical imaging; Spatial resolution;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1989. Images of the Twenty-First Century., Proceedings of the Annual International Conference of the IEEE Engineering in

Conference_Location

Seattle, WA

Type

conf

DOI

10.1109/IEMBS.1989.96161

Filename

96161