Detection of tissue thermal damage using quantitative histology

Author

Thomsen, Sharon ; Pearce, John A. ; Cheong, Wei-Fung

Author_Institution

Texas Univ., M.D. Anderson Cancer Center, Houston, TX, USA

fYear

1989

fDate

9-12 Nov 1989

Firstpage

1211

Abstract

Loss and changes of the native form birefringence in heated striated skeletal and cardiac muscle, smooth muscle and collagen are discussed as histologic markers of thermal damage. The thresholds at which the birefringence changes occur depend on temperature and exposure time and vary among the different tissue types. The sharp boundaries of birefringence changes and certain other histologic markers of thermal damage can be measured to verify mathematical and physical models of heat distribution in tissues

Keywords

biological techniques and instruments; biothermics; birefringence; muscle; cardiac muscle; collagen; exposure time; heat distribution; heat striated skeletal muscle; histologic markers; mathematical models; native form birefringence; physical models; quantitative histology; sharp boundaries; smooth muscle; temperature; tissue thermal damage; Biomedical engineering; Biomedical imaging; Birefringence; Cancer; Lesions; Muscles; Propagation losses; Temperature; Thermal engineering; Transmission electron microscopy;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1989. Images of the Twenty-First Century., Proceedings of the Annual International Conference of the IEEE Engineering in

Conference_Location

Seattle, WA

Type

conf

DOI

10.1109/IEMBS.1989.96164

Filename

96164