Title :
Detection of tissue thermal damage using quantitative histology
Author :
Thomsen, Sharon ; Pearce, John A. ; Cheong, Wei-Fung
Author_Institution :
Texas Univ., M.D. Anderson Cancer Center, Houston, TX, USA
Abstract :
Loss and changes of the native form birefringence in heated striated skeletal and cardiac muscle, smooth muscle and collagen are discussed as histologic markers of thermal damage. The thresholds at which the birefringence changes occur depend on temperature and exposure time and vary among the different tissue types. The sharp boundaries of birefringence changes and certain other histologic markers of thermal damage can be measured to verify mathematical and physical models of heat distribution in tissues
Keywords :
biological techniques and instruments; biothermics; birefringence; muscle; cardiac muscle; collagen; exposure time; heat distribution; heat striated skeletal muscle; histologic markers; mathematical models; native form birefringence; physical models; quantitative histology; sharp boundaries; smooth muscle; temperature; tissue thermal damage; Biomedical engineering; Biomedical imaging; Birefringence; Cancer; Lesions; Muscles; Propagation losses; Temperature; Thermal engineering; Transmission electron microscopy;
Conference_Titel :
Engineering in Medicine and Biology Society, 1989. Images of the Twenty-First Century., Proceedings of the Annual International Conference of the IEEE Engineering in
Conference_Location :
Seattle, WA
DOI :
10.1109/IEMBS.1989.96164
