Title :
Optimal design of scan intervals for glucose kinetic modeling using dynamic imaging data from PET
Author :
Li, X. ; Feng, D.
Author_Institution :
Dept. of Comput. Sci., Sydney Univ., NSW, Australia
Abstract :
In tracer kinetic modeling with positron emission tomography (PET) it is required to take the tracer tissue time-activity images which are of accumulated counts corresponding to the scan intervals. In this paper, the optimal design of the scan intervals to estimate metabolic rate of glucose (MRGlc) is investigated. Specific features of the PET measurements are considered. The results show that, if the scan intervals are selected properly, the number of dynamic images required can be reduced by approximately 75%, the time for data analysis can be reduced, and the accuracy of parameter estimation can be improved
Keywords :
blood; parameter estimation; positron emission tomography; radioactive tracers; PET; data analysis time; dynamic images; dynamic imaging data; glucose kinetic modeling; metabolic rate; optimal design; parameter estimation accuracy; positron emission tomography; scan intervals; tracer kinetic modeling; tracer tissue time-activity images; Blood; Data analysis; Image sampling; Image storage; Kinetic theory; Parameter estimation; Positron emission tomography; Protocols; Sampling methods; Sugar;
Conference_Titel :
Engineering in Medicine and Biology Society, 1994. Engineering Advances: New Opportunities for Biomedical Engineers. Proceedings of the 16th Annual International Conference of the IEEE
Conference_Location :
Baltimore, MD
Print_ISBN :
0-7803-2050-6
DOI :
10.1109/IEMBS.1994.411838
