Title :
A compartmental model of oxygen transport derived from a distributed model: treatment of convective and oxygen dissociation properties
Author :
Ye, Guo-Fan ; Moore, Thomas W. ; Jaron, Dov
Author_Institution :
Biomed. Eng. & Sci. Inst., Drexel Univ., Philadelphia, PA, USA
Abstract :
The authors derive a compartmental model for oxygen transport in vascular blood which is suitable for both steady and time-varying analysis, and which can be used with any kind of oxygen dissociation function. The derivation focuses on the establishment of expressions for the lumped convective term and the lumped oxygen dissociation function. Results of the simulation show that the value of the lumped convective term in the present model is significantly larger than that found in previously published models, and that the value computed from the present lumped oxygen dissociation function, while not significantly different under normal or mildly hypoxic conditions from that used in the other models, becomes significantly larger under severe hypoxia.
Keywords :
biodiffusion; blood; cellular transport and dynamics; haemorheology; oxygen; physiological models; O; brain capillary model; compartmental model; distributed model; lumped convective term; lumped oxygen dissociation function; mildly hypoxic conditions; normal conditions; oxygen dissociation properties; oxygen transport; severe hypoxia; simulation; steady analysis; time-varying analysis; vascular blood; Biomedical engineering; Blood; Computational modeling; Distributed computing; Distribution functions; Medical treatment; Nonlinear equations; Oxygen; Shape; Sociotechnical systems;
Conference_Titel :
Bioengineering Conference, 1992., Proceedings of the 1992 Eighteenth IEEE Annual Northeast
Conference_Location :
Kingston, RI, USA
Print_ISBN :
0-7803-0902-2
DOI :
10.1109/NEBC.1992.285965