Simulation and analysis of nerve growth cone-target encounter

Author

Thompson, Deanna M. ; Buettner, Helen M.

Author_Institution

Dept. of Chem. & Biochem. Eng., Rutgers Univ., Piscataway, NJ, USA

fYear

1996

fDate

14-15 Mar 1996

Firstpage

34

Lastpage

35

Abstract

Investigation of nerve development and regeneration has revealed that the leading tip of the growing axon, the growth cone, can influence the rate and direction of growth. The filopodia especially have been implicated in a path finding role. However, due to their dynamic behavior, it has been difficult to quantitatively describe their contribution. To address this problem, the authors have applied a mathematical model of filopodial dynamics to examine path finding behavior. The model simulates the time required for a filopodium to contact a target at a distance, d, from the growth cone

Keywords

cellular biophysics; neurophysiology; physiological models; dynamic behavior; filopodial dynamics; growing axon leading tip; growth direction; growth rate; mathematical model; nerve development; nerve growth cone-target encounter; nerve regeneration; path finding role; Analytical models; Chemical engineering; Mathematical model; Navigation; Nerve fibers; Nervous system; Probability distribution; Regeneration engineering; Stochastic processes;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 1996., Proceedings of the 1996 IEEE Twenty-Second Annual Northeast

Conference_Location

New Brunswick, NJ

Print_ISBN

0-7803-3204-0

Type

conf

DOI

10.1109/NEBC.1996.503204

Filename

503204