• DocumentCode
    1814456
  • Title

    Molecular modeling of the histamine H1 receptor

  • Author

    Gerula, Christine ; Yadav, Janardon ; Kristol, David ; Ritter, Arthur

  • Author_Institution
    New Jersey Inst. of Technol., Newark, NJ, USA
  • fYear
    1992
  • fDate
    1992
  • Firstpage
    156
  • Abstract
    Summary form only given. The authors review the properties and functional characteristics of the H1 receptor and postulate the nature of the ligand-receptor activation site using molecular modeling techniques. A model of the surface of the active site on the receptor was postulated and constructed using Sybyl software on a personal Iris workstation. The surface properties were inferred using the structure-activity relationships for the competitive antagonists which have been reported in the literature.
  • Keywords
    biology computing; cellular biophysics; microcomputer applications; molecular biophysics; proteins; Sybyl software; active site; cells; competitive antagonists; functional characteristics; histamine H1 receptor; inflammatory process mediator; ligand-receptor activation site; molecular modeling; personal Iris workstation; structure-activity relationships; surface properties; Amino acids; Inhibitors; Iris; Neurons; Workstations;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Bioengineering Conference, 1992., Proceedings of the 1992 Eighteenth IEEE Annual Northeast
  • Conference_Location
    Kingston, RI, USA
  • Print_ISBN
    0-7803-0902-2
  • Type

    conf

  • DOI
    10.1109/NEBC.1992.286001
  • Filename
    286001
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=1814456