Title :
Molecular modeling of the histamine H1 receptor
Author :
Gerula, Christine ; Yadav, Janardon ; Kristol, David ; Ritter, Arthur
Author_Institution :
New Jersey Inst. of Technol., Newark, NJ, USA
Abstract :
Summary form only given. The authors review the properties and functional characteristics of the H1 receptor and postulate the nature of the ligand-receptor activation site using molecular modeling techniques. A model of the surface of the active site on the receptor was postulated and constructed using Sybyl software on a personal Iris workstation. The surface properties were inferred using the structure-activity relationships for the competitive antagonists which have been reported in the literature.
Keywords :
biology computing; cellular biophysics; microcomputer applications; molecular biophysics; proteins; Sybyl software; active site; cells; competitive antagonists; functional characteristics; histamine H1 receptor; inflammatory process mediator; ligand-receptor activation site; molecular modeling; personal Iris workstation; structure-activity relationships; surface properties; Amino acids; Inhibitors; Iris; Neurons; Workstations;
Conference_Titel :
Bioengineering Conference, 1992., Proceedings of the 1992 Eighteenth IEEE Annual Northeast
Conference_Location :
Kingston, RI, USA
Print_ISBN :
0-7803-0902-2
DOI :
10.1109/NEBC.1992.286001
