Effect of skin preparation on transdermal insulin delivery

Author

Cawley, Peter J. ; Zakzewski, Christine ; Wasilewski, Jacek ; Ford, William, Jr.

Author_Institution

Dept. of Biol., Scranton Univ., PA, USA

fYear

1996

fDate

14-15 Mar 1996

Firstpage

50

Lastpage

51

Abstract

Insulin was delivered transdernally to diabetic rats using pulsed iontophoresis. Rats were shaved with electric shears 48 hours prior to iontophoretic treatment. The first iontophoretic group (n=4) had Nair applied on the day of the experiment to remove hair stubble. The second iontophoretic group (n=4) had Nair applied 24 hours before the study. The third iontophoretic group (n=4) did not have Nair applied. Our results indicate that blood glucose levels (BGL) fell on average by 68% affer 1 hour of iontophoresis in the group treated with Nair on the day of the study. In rats treated with Nair 24 hours prior, BGL remained near initial values. Animals not treated with Nair had BGL which fell only slightly within one hour of the start of iontophoresis

Keywords

bioelectric phenomena; biomedical equipment; blood; electrophoresis; patient treatment; skin; 1 hour; 24 hour; 48 hour; Nair; animals; blood glucose levels; diabetic rats; electric shears; hair stubble; iontophoretic treatment; pulsed iontophoresis; skin preparation; transdermal insulin delivery; Animals; Blood; Chemistry; Diabetes; Drugs; Insulin; Medical treatment; Rats; Skin; Sugar;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 1996., Proceedings of the 1996 IEEE Twenty-Second Annual Northeast

Conference_Location

New Brunswick, NJ

Print_ISBN

0-7803-3204-0

Type

conf

DOI

10.1109/NEBC.1996.503212

Filename

503212