Design of a mode of delivery for macrobead transplantation

Author

Desai, Jagdip ; Jain, Kanti

Author_Institution

New Jersey Inst. of Technol., Newark, NJ, USA

fYear

1996

fDate

14-15 Mar 1996

Firstpage

52

Lastpage

53

Abstract

The macrobead, a biohybrid artificial pancreas (BAP), is used to treat type 1 diabetes. A hypothetical human transplantation would require 125 rat equivalent macrobeads. A mode of delivery that allows the placement of several hundred macrobeads into a basket or pouch type device is required. Four commercially available materials were identified as possible candidates for creating a pouch: polyvinyl chloride acrylic copolymer (PVC), polyether sulfone (PES), polyvinylidene difluoride (PVD), and polytetrafluorethylene (PTFE-teflon). Pouches of each material underwent in vivo biocompatibility and in vitro permeability examinations. Based on the results PES and PVD appear suitable for creating a pouch to hold a large number of marobeads

Keywords

artificial organs; basket-type device; commercially available materials; delivery mode; hypothetical human transplantation; in vitro permeability; in vivo biocompatibility; macrobead transplantation; polyether sulfone; polytetrafluorethylene; polyvinyl chloride acrylic copolymer; polyvinylidene difluoride; pouch type device; rat equivalent macrobeads; type 1 diabetes treatment; Atherosclerosis; Biological materials; Biomembranes; Blood; Diabetes; In vivo; Insulin; Pancreas; Protection; Sugar;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 1996., Proceedings of the 1996 IEEE Twenty-Second Annual Northeast

Conference_Location

New Brunswick, NJ

Print_ISBN

0-7803-3204-0

Type

conf

DOI

10.1109/NEBC.1996.503213

Filename

503213