Title :
Nonlinear microscopy of living tumors and their treatment
Author :
Brown, Edward ; Jain, Rakesh K.
Author_Institution :
Dept. of Biomed. Eng., Rochester Univ. Medical Center, NY
Abstract :
We will discuss the application of the multiphoton laser-scanning microscope (MPLSM) to the study of the tumor microenvironment. This will include its use in the quantification of angiogenic parameters and the study of tumor vessel permeability. We also will explore the use of an intrinsic contrast mechanism, second harmonic generation, to quantify modification of the tumor extracellular matrix, with the ultimate goal of improving therapeutic efficacy
Keywords :
biomedical optical imaging; cellular biophysics; laser applications in medicine; multiphoton processes; optical harmonic generation; optical microscopy; patient treatment; permeability; tumours; Al2O3:Ti; angiogenic parameters; intrinsic contrast mechanism; living tumors; multiphoton laser-scanning microscope; nonlinear microscopy; second harmonic generation; therapeutic efficacy; tumor extracellular matrix; tumor microenvironment; tumor treatment; tumor vessel permeability; Biomedical engineering; Biomedical imaging; Biomedical optical imaging; Blood vessels; Density measurement; Frequency conversion; Neoplasms; Optical imaging; Optical microscopy; Permeability;
Conference_Titel :
Biomedical Imaging: Nano to Macro, 2006. 3rd IEEE International Symposium on
Conference_Location :
Arlington, VA
Print_ISBN :
0-7803-9576-X
DOI :
10.1109/ISBI.2006.1624929
