Title :
Illuminating disease with fluorescence molecular tomography
Author :
Ntziachristos, Vasilis
Author_Institution :
Center for Molecular Imaging Res., Harvard Medical Sch., Charlestown, MA
Abstract :
The combination of advanced macroscopic visualization methods with the ability to impart molecular contrast in-vivo in whole tissues offers an exciting new tool with large potential in basic research, drug discovery and clinical application. One of the most recent technological evolutions has been the development of fluorescence tomography for visualization at the whole animal or tissue level. This technology allows for three dimensional imaging of fluorescence bio-distribution in whole animals, is insensitive to optical tissue heterogeneity and offers great promise as a versatile platform for non-invasive fluorescence imaging. Key technological advances in the field are herein summarized
Keywords :
biological tissues; biomedical optical imaging; diseases; fluorescence; molecular biophysics; optical tomography; advanced macroscopic visualization; disease; fluorescence biodistribution; fluorescence molecular tomography; molecular contrast; noninvasive fluorescence imaging; three dimensional imaging; whole animals; whole tissues; Animals; Biomedical optical imaging; Diseases; Fluorescence; Optical imaging; Optical sensors; Peptides; Probes; Tomography; Visualization;
Conference_Titel :
Biomedical Imaging: Nano to Macro, 2006. 3rd IEEE International Symposium on
Conference_Location :
Arlington, VA
Print_ISBN :
0-7803-9576-X
DOI :
10.1109/ISBI.2006.1624931
