Amphiphilic polymeric nanoparticles for drug delivery: Synthesis and characterization

The aim of this study is to prepare amphiphilic biodegradable core-shell nanoparticles using poly(3hydroxybutyrate-co-4hydroxybutyrate) copolymer as hydrophobic core and monomethoxy poly(ethylene glycol) as outer hydrophilic shell. The nanoparticles were prepared by emulsification-solvent evaporation technique using sodium deoxycholate as emulsifier. Particle size, surface morphology and zeta potential were measured by DLS, FE-SEM and ELS, respectively. Characterization of the nanoparticles shows the formation of spherically shaped nanoparticles with mean particle size range of 100 to 200 nm and zeta potential of -22 mV. The modified nanoparticles could be used as better source for drug delivery, ameliorating the toxicity associated with PHA based drug delivery materials.