Development of inhibitory and facilitatory modulation in the rat dentate gyrus

Author

Blaise, J.H. ; Austin-LaFrance, R.J. ; Bronzino, J.D.

Author_Institution

Dept. of Eng. & Comput. Sci., Trinity Coll., Hartford, CT, USA

fYear

1996

fDate

14-15 Mar 1996

Firstpage

89

Lastpage

90

Abstract

The present study was undertaken to examine age-related changes in the facilitatory/inhibitory modulation of dentate granule cell excitability in the hippocampus of freely-moving male rats. Dentate granule cell population responses to paired-pulse stimulation of the perforant pathway were recorded across a range of interpulse intervals at 15, 30 and 90 days of age. Paired-pulse indexes were constructed based on the percent change in the response to the second pulse from the response to the first pulse. Results indicate an age-dependent rise in the level of both inhibitory and facilitatory modulation of dentate granule cell excitability. The results indicate that the relationship between inhibitory neurons and dentate granule cells depends on the maturational state of the local hippocampal circuit

Keywords

bioelectric phenomena; brain; cellular biophysics; neurophysiology; 0.041 to 0.246 yr; age-related changes; facilitatory modulation; freely-moving male rats; inhibitory modulation; inhibitory neurons; local hippocampal circuit; maturational state; paired-pulse index; paired-pulse stimulation; perforant pathway; rat dentate gyrus; Circuits; Computer science; Electrodes; Embryo; Hippocampus; In vitro; Neurons; Pulse measurements; Pulse modulation; Rats;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 1996., Proceedings of the 1996 IEEE Twenty-Second Annual Northeast

Conference_Location

New Brunswick, NJ

Print_ISBN

0-7803-3204-0

Type

conf

DOI

10.1109/NEBC.1996.503231

Filename

503231