Title :
25 Years of SA Nodal Cell Modeling
Author_Institution :
Univ. of Amsterdam, Amsterdam
Abstract :
This review provides a brief history of modeling the spontaneous electrical activity of sinoatrial (SA) nodal cells. The first mathematical models of the pacemaker activity of these cells were published in the early 1980s. During the 25 years that followed, many more models of increasing complexity have been developed. The main characteristics of the twelve most widely used models are presented and compared.
Keywords :
bioelectric potentials; biomembrane transport; blood vessels; cardiology; cellular biophysics; pacemakers; physiological models; SA nodal cell modeling; mammalian heart; pacemaker activity; sarcolemmal ionic currents; sinoatrial nodal cells activity; spontaneous electrical activity; time 25 year; transmembrane potential; Biomembranes; Calcium; Capacitance; Delay; Equations; Mathematical model; Pacemakers; Rabbits; Rectifiers; Voltage; Animals; Heart; Membrane Potentials; Models, Cardiovascular; Rabbits; Sinoatrial Node;
Conference_Titel :
Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE
Conference_Location :
Lyon
Print_ISBN :
978-1-4244-0787-3
DOI :
10.1109/IEMBS.2007.4352245
