Title :
Desynchronization of epileptiform activity by phase resetting
Author :
Warman, E. ; Durand, D.
Author_Institution :
Dept. of Biomed. Eng., Case Western Reserve Univ., Cleveland, OH, USA
Abstract :
Perturbational studies were performed on an epileptic model, and a singular stimulus which induced cessation of the repetitive extracellular firing was found. The mechanism probably involved in this extracellular phenomenon is a desynchronization of the individual neuronal firings, as suggested by the intracellular recordings obtained. The use of these techniques to study the possibility of controlling abnormal neuronal activity found in epilepsy is proposed
Keywords :
bioelectric phenomena; neurophysiology; physiological models; abnormal neuronal activity control; epileptic model; epileptiform activity desynchronization; intracellular recordings; perturbation; phase resetting; repetitive extracellular firing; Biomedical engineering; Biomedical measurements; Control systems; Epilepsy; Extracellular; Frequency; Laboratories; Neurons; Oscillators; Rhythm;
Conference_Titel :
Engineering in Medicine and Biology Society, 1989. Images of the Twenty-First Century., Proceedings of the Annual International Conference of the IEEE Engineering in
Conference_Location :
Seattle, WA
DOI :
10.1109/IEMBS.1989.96197
