Title :
Collective oscillations in the CA3 region of the guinea pig hippocampal slice
Author_Institution :
IBM Thomas J. Watson Res. Center, Yorktown Heights, NY, USA
Abstract :
A detailed model of the in vitro guinea pig hippocampal CA3 region has been constructed, using three neuronal types (pyramidal cells and two kinds of inhibitory cell). The model cells (up to 9900 of them) have dendrites and voltage-dependent and calcium-dependent conductances. The connectivity and unitary synaptic actions are defined experimentally by dual intracellular recordings. The model generates two basic types of oscillation: with inhibition blocked, synchronized epileptiform bursts occur at low rates; with inhibition present, low-amplitude population oscillations occur in which individual cells do not fire periodically. Both sorts of activity are observed in experiments
Keywords :
bioelectric phenomena; brain; cellular biophysics; neurophysiology; Ca dependent conductances; collective oscillations; connectivity; dendrites; dual intracellular recordings; in vitro guinea pig hippocampal CA3 region; inhibitory cell; low-amplitude population oscillations; model cells; neuronal types; pyramidal cells; synchronized epileptiform bursts; unitary synaptic actions; voltage dependent conductances; Brain modeling; Chaos; Electroencephalography; Epilepsy; Fires; Frequency synchronization; Humans; In vitro; Signal generators; Voltage;
Conference_Titel :
Engineering in Medicine and Biology Society, 1989. Images of the Twenty-First Century., Proceedings of the Annual International Conference of the IEEE Engineering in
Conference_Location :
Seattle, WA
DOI :
10.1109/IEMBS.1989.96198
