Compensating for patient respiration in PET/CT imaging with the registered and summed phases (RASP) procedure

Author

Kinahan, Paul ; MacDonald, Lawrence ; Ng, Lydia ; Alessio, Adam ; Segars, Paul ; Tsui, Benjamin ; Pathak, Sayan

Author_Institution

Dept. of Radiol., Washington Univ., Seattle, WA

fYear

2006

fDate

6-9 April 2006

Firstpage

1104

Lastpage

1107

Abstract

PET/CT imaging has introduced new challenges in accurate quantitation of lung nodules due to respiratory motion and mismatches in CT-based attenuation correction (CTAC). We used Monte Carlo simulations to investigate how respiratory-correlated CTAC can be optimized to account for mis-registration between the AC data and the PET data due to respiratory motion. This step also allows compensating for increased emission noise in respiratory-gated PET images by non-rigid image registration of the CTAC phases. These registration parameters are then applied to the attenuation-corrected PET phase images, which are then summed to reduce noise. A significant increase in the final PET SNR is demonstrated

Keywords

Monte Carlo methods; image registration; lung; medical image processing; motion compensation; pneumodynamics; positron emission tomography; CT imaging; CT-based attenuation correction; Monte Carlo simulations; PET; lung nodules; motion compensation; nonrigid image registration; patient respiration; respiratory motion; summed phases procedure; Anatomy; Attenuation; Cancer; Computed tomography; Degradation; Lungs; Noise reduction; Phase noise; Positron emission tomography; Radiology;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Imaging: Nano to Macro, 2006. 3rd IEEE International Symposium on

Conference_Location

Arlington, VA

Print_ISBN

0-7803-9576-X

Type

conf

DOI

10.1109/ISBI.2006.1625115

Filename

1625115