High-resolution functional optical imaging of living tissues

Author

Hillman, Elizabeth M.C. ; Devor, Anna ; Boas, David A.

Author_Institution

Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts Gen. Hosp., Boston, MA

fYear

2006

fDate

6-9 April 2006

Firstpage

1192

Lastpage

1195

Abstract

Laminar optical tomography (LOT) is an optical imaging technique capable of imaging absorption and fluorescence contrast in-vivo to depths of >2mm with 100-200 micron resolution. LOT has been used to image the living brain in experiments to investigate the hemodynamic response in rat cortex during forepaw stimulus. We show that using LOT, it is possible to resolve the contributions of each vascular compartment to the ensemble hemodynamic response. The LOT system will be described and its future application to other areas of medical imaging will be discussed

Keywords

biological tissues; biomedical optical imaging; brain; fluorescence; haemodynamics; light absorption; medical image processing; optical tomography; brain; ensemble hemodynamic response; fluorescence contrast; forepaw stimulus; high-resolution functional optical imaging; laminar optical tomography; living tissues; medical imaging; optical absorption; rat cortex; Biomedical optical imaging; Focusing; High-resolution imaging; Image resolution; Light scattering; Optical fibers; Optical imaging; Optical microscopy; Optical scattering; Tomography;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Imaging: Nano to Macro, 2006. 3rd IEEE International Symposium on

Conference_Location

Arlington, VA

Print_ISBN

0-7803-9576-X

Type

conf

DOI

10.1109/ISBI.2006.1625137

Filename

1625137