Title :
Geometry-driven visualization of microscopic structures in biology
Author :
Mosaliganti, K. ; Machiraju, Raghu ; Huang, K.
Author_Institution :
Comput. Sci. & Eng., Ohio State Univ., Columbus, OH
Abstract :
There are natural geometric patterns in biology. Tissue layers, for example, differ mainly in the spatial distributions, size and packing of microstructure components such as the red blood cells, nuclei and cytoplasm etc. Expressive visualization by using the N-point correlation functions, involves the discovery of feature spaces that estimate and spatially delineate component distributions unique to a salient tissue. These functions provide feature spaces that are used to set useful transfer functions. We obtain insightful 3D visualizations of the epithelial cell lining in mouse mammary ducts and evolving structures in a zebrafish embryo. These are large datasets acquired from light and confocal microscopy scanners respectively.
Keywords :
biological techniques; biological tissues; cellular biophysics; correlation methods; optical microscopy; N-point correlation functions; biological tissue; biology; cell nuclei; component distributions; confocal microscopy scanners; cytoplasm; epithelial cell lining; geometry-driven visualization; light microscopy; microscopic structures; microstructure components; mouse mammary ducts; natural geometric patterns; red blood cells; zebrafish embryo; Biology; Cells (biology); Ducts; Microscopy; Microstructure; Shape; Statistical distributions; Surface morphology; Transfer functions; Visualization; N-point functions; microscopy imaging; tissue segmentation;
Conference_Titel :
Biomedical Imaging: From Nano to Macro, 2008. ISBI 2008. 5th IEEE International Symposium on
Conference_Location :
Paris
Print_ISBN :
978-1-4244-2002-5
Electronic_ISBN :
978-1-4244-2003-2
DOI :
10.1109/ISBI.2008.4541124