Title :
New Physiological Model of Serum Creatine Phosphokinase Activity in Acute Myocardial Infarction. --- Estimation of the Total Creatine Phosphokinase Release
Author :
Kitawaki, T. ; Oka, H. ; Kusachi, S. ; Himeno, R.
Author_Institution :
Okayama Univ., Okayama
Abstract :
In this report, we introduce a new physiological model of the serum creatine phosphokinase (CPK) activity change, that is useful for estimating the total CPK release accurately even with reduced blood sampling frequency. The physiological model was applied to the serum CPK activity change of patients who suffered acute myocardial infarction (AMI), and the model showed good agreement with the serum CPK activity. In addition, the calculated value of total CPK release agreed well with that calculated using the conventional technique.
Keywords :
biomedical measurement; blood; cardiology; cellular biophysics; diseases; enzymes; molecular biophysics; physiological models; acute myocardial infarction; blood sampling; enzyme; muscle cells; muscle contraction; physiological model; serum creatine phosphokinase; Ambient intelligence; Arteries; Biochemistry; Biomembranes; Blood flow; Cells (biology); Frequency estimation; Muscles; Myocardium; Sampling methods; Aged; Aged, 80 and over; Biological Markers; Computer Simulation; Creatine Kinase; Diagnosis, Computer-Assisted; Enzyme Activation; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Models, Cardiovascular; Myocardial Infarction; Reproducibility of Results; Sensitivity and Specificity;
Conference_Titel :
Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE
Conference_Location :
Lyon
Print_ISBN :
978-1-4244-0787-3
DOI :
10.1109/IEMBS.2007.4352439
