Continuous Ejection Fraction Estimation by Model-Based Analysis of an Aortic Pressure Waveform: Comparison to Echocardiography

Left ventricular ejection fraction (EF) is perhaps the most clinically significant index of global ventricular function. EF is measured in clinical practice using imaging methods such as non-invasive echocardiography. However, imaging methods generally require a skilled operator and expensive equipment. Thus, EF is not sufficiently monitored. To this end, we have recently developed a novel technique to continuously (i.e., automatically) estimate EF by model-based analysis of an aortic pressure waveform. Here, we review the technique and present its evaluation with respect to reference echocardiography measurements from three dogs during diverse interventions. We report an overall EF error of only 8.3%. With further successful testing, the technique may ultimately be utilized for continuous EF monitoring in research and clinical settings in which an aortic catheter is employed.