Irregular high frequency patterns decrease the effectiveness of deep brain stimulation in a rat model of Parkinson´s disease

Author

So, R.Q. ; McConnell, G.C. ; Hilliard, J.D. ; Grill, Warren M.

Author_Institution

Dept. of Biomed. Eng., Duke Univ., Durham, NC, USA

fYear

2011

fDate

April 27 2011-May 1 2011

Firstpage

322

Lastpage

325

Abstract

Deep brain stimulation (DBS) is an effective treatment of Parkinson´s disease, but its mechanisms are still unclear. To test the hypothesis that DBS alleviates motor symptoms by regularizing neuronal firing, we applied regular frequency stimulation between 5-260 Hz as well as irregular high frequency stimulation with an average rate of 130Hz to rats with unilateral 6-hydroxydopamine (6-OHDA) lesions. We found that high frequency regular stimulation above 130Hz was more effective than both low frequency stimulation and high frequency irregular stimulation at normalizing pathological circling behavior. Our results support the hypothesis that DBS is effective because it is able to mask pathological firing patterns within the basal ganglia, and highlight the importance of the temporal pattern in addition to the rate of stimulation.

Keywords

diseases; neuromuscular stimulation; Parkinson disease rat model; basal ganglia; deep brain stimulation; frequency 5 Hz to 260 Hz; high frequency stimulation; irregular high frequency patterns; motor symptoms; neuronal firing; pathological circling behavior; pathological firing patterns; unilateral 6-hydroxydopamine lesions; Angular velocity; Basal ganglia; Brain stimulation; Firing; Neurons; Rats; Satellite broadcasting;

fLanguage

English

Publisher

ieee

Conference_Titel

Neural Engineering (NER), 2011 5th International IEEE/EMBS Conference on

Conference_Location

Cancun

ISSN

1948-3546

Print_ISBN

978-1-4244-4140-2

Type

conf

DOI

10.1109/NER.2011.5910552

Filename

5910552