Title :
Leading to Long-Term Nonprogressor via Gradual Reduction of Drug Dose with Immune Dynamics Strongly Dependant on Target Cells
Author :
Chang, H. ; Astolfi, A.
Author_Institution :
Imperial Coll. London, London
Abstract :
For a HIV dynamic model with immune system which strongly depends on the HIV target cells, we apply a recently proposed drug scheduling scheme: gradual reduction of drug dose. The feasibility of this scheme is analysed rigorously. By means of this method, the HIV patient is steered to an equilibrium condition known as long-term nonprogressor, which corresponds to an infected status not developing the symptoms of AIDS.
Keywords :
cellular biophysics; diseases; drugs; microorganisms; physiological models; AIDS; HIV dynamic model; HIV target cells; drug dose reduction; drug scheduling scheme; immune dynamics; immune system; long-term nonprogressor; Acquired immune deficiency syndrome; Bifurcation; Blood; Drugs; Dynamic scheduling; Human immunodeficiency virus; Immune system; Mathematical model; Medical diagnostic imaging; Production facilities; Anti-HIV Agents; CD4-Positive T-Lymphocytes; Computer Simulation; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Delivery Systems; Drug Therapy, Computer-Assisted; HIV Infections; Humans; Models, Immunological;
Conference_Titel :
Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE
Conference_Location :
Lyon
Print_ISBN :
978-1-4244-0787-3
DOI :
10.1109/IEMBS.2007.4352486
