Title :
Mechanism of Permeation in Calcium Channels Activation by Applied Magnetic Fields
Author :
Zhang Yu-Hong ; Zhan Yong ; Zhao Tong-Jun ; Han Ying-Rong ; Liu Hui
Author_Institution :
Hebei Univ. of Technol., Tianjin
Abstract :
In this paper, a Brownian dynamics model of cell membrane calcium ion channels exposure to ELF magnetic fields has been proposed for the first time. Based on the model, the permeation of calcium channels activation by applied magnetic fields is given here. The number of opened calcium channel is increase with magnetic fields. The currents of calcium ions in the channel in controls and exposure to ELF magnetic fields are almost the same. These results are consistent with experiments. Thus it can be seen that the current of single calcium channel was nearly unaffected by applied magnetic fields, the increased number of opened calcium channel may be the reason of increased intracellular calcium concentration.
Keywords :
Brownian motion; bioelectric phenomena; biological effects of fields; biomembrane transport; Brownian dynamics; applied magnetic fields; calcium ion channels activation; cell membrane; permeation mechanism; Biomembranes; Calcium; Cells (biology); Cyclotrons; Electromagnetic fields; Geophysical measurement techniques; Ground penetrating radar; Magnetic fields; Magnetic resonance; Plasmas; Calcium; Calcium Channels; Cell Membrane Permeability; Computer Simulation; Dose-Response Relationship, Radiation; Electromagnetic Fields; Ion Channel Gating; Models, Biological; Radiation Dosage;
Conference_Titel :
Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE
Conference_Location :
Lyon
Print_ISBN :
978-1-4244-0787-3
DOI :
10.1109/IEMBS.2007.4352558