Title :
Synthesis & characterization of iron-carboxylate nanoscale metal organic frameworks for drug delivery
Author :
Gupta, Vandana ; Paul, A.K. ; Tyagi, Sachin
Author_Institution :
Central Sci. Instrum. Organ., Chandigarh, India
Abstract :
MIL-101-Fe (Materials of Institute Lavoisier) nanoscale-metal organic frameworks (NMOFs) were synthesized by solvothermal method with constant heating at 200°C in silicon oil bath. The as prepared MIL-101-Fe nanoparticles are observed to have particle size in the range of 200-210 nm with multiple shape morphology. Further as prepared MIL-101-Fe are functionalized by incorporating amine group into the framework. Drug loaded NMOF were coated with silica to control the rate of release of drug by avoiding rapid degradation of the NMOF in alkaline pH of PBS buffer. The drug release profile showed that the drug from MIL-101-Fe is released completely in ~32 hrs while for SiO2@Drug@ MIL-101-Fe is extended upto 75 hrs. Silica coated SiO2@Drug@ NH2-MIL-101-Fe particles had adequate stability for drug delivery application.
Keywords :
biomedical materials; drug delivery systems; drugs; iron compounds; materials preparation; nanomedicine; nanoparticles; organic compounds; pH; silicon compounds; SiO2; alkaline pH; amine group; constant heating; drug delivery application; iron-carboxylate nanoscale metal organic frameworks; multiple shape morphology; silicon oil bath; size 200 nm to 210 nm; solvothermal method; temperature 200 degC; time 75 hr; Coatings; Drug delivery; Drugs; Heating; Metals; Nanoparticles; Silicon compounds; diffusion; drug; functionalization;
Conference_Titel :
Physics and Technology of Sensors (ISPTS), 2015 2nd International Symposium on
Conference_Location :
Pune
DOI :
10.1109/ISPTS.2015.7220125
