DocumentCode
1830002
Title
The effect of parameter uncertainty on a novel insulin bolus calculator
Author
Palma, Rodrigo ; Edgar, Thomas F.
Author_Institution
Dept. of Chem. Eng., Univ. of Texas at Austin, Austin, TX, USA
fYear
2010
fDate
7-10 Sept. 2010
Firstpage
1
Lastpage
5
Abstract
A simple control law is derived from the eponymous Bergman Minimal Model with the aim of implementing patient specific insulin injections. The Fisher Information Matrix is used to form an approximate necessary condition for the a posteriori identifiability of the Bergman Minimal Model´s parameters from home-use continuous glucose measurements. It is shown that despite parameter uncertainty control moves based on the control law are not subject to physiologically significant variability.
Keywords
matrix algebra; maximum likelihood estimation; medical control systems; Fisher information matrix; a posteriori identifiability; eponymous Bergman minimal model; home-use continuous glucose measurements; insulin bolus calculator; parameter uncertainty control; patient specific insulin injections; biomedical systems; identifiability; physiological models; sensitivity analysis; system identification;
fLanguage
English
Publisher
iet
Conference_Titel
Control 2010, UKACC International Conference on
Conference_Location
Coventry
Electronic_ISBN
978-1-84600-038-6
Type
conf
DOI
10.1049/ic.2010.0387
Filename
6490845
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