Investigation of signal averaging on image quality in positron emission tomography

Author

Balakrishnan, Karthikayan ; Hichwa, Richard D. ; Grabowski, Thomas J. ; Madsen, Mark T. ; Ponto, Laura L. ; Watkins, G. Leonard ; Richmond, John C. ; Bender, Benjamin

Author_Institution

Dept. of Phys. & Astron., Iowa Univ., Iowa City, IA, USA

Volume

4

fYear

2003

fDate

19-25 Oct. 2003

Firstpage

2849

Abstract

Conventional [¹⁵O]water PET rCBF methodology is composed of 1-10 injections of 10-50 mCi associated with multiple brain activation conditions (between 1-10). Injections occur at 10-15 min intervals. The current research compares the regional CBF signal using conventional PET studies with a method that involves summing data from 50-100 low dose injections (1-5 mCi) that have been administered in rapid but uniform succession (occurs at 1-2 min intervals) over a total study duration of 1-2 hours. This design allows for single subject studies. PET data from multiple occurrences are simulated for each specific activation condition and are summed to create a high statistics image for each activation condition. The results from the simulation are to be used to develop a computer controlled injection and data acquisition system.

Keywords

brain; data acquisition; haemorheology; medical computing; medical image processing; positron emission tomography; PET data; [¹⁵O]water PET rCBF methodology; computer controlled injection; data acquisition system; data summing; high statistics image; image quality; low dose injections; multiple brain activation conditions; regional CBF signal; signal averaging; Brain modeling; Cities and towns; Computational modeling; Computer simulation; Current measurement; Data acquisition; Extraterrestrial measurements; Image quality; Positron emission tomography; Statistics;

fLanguage

English

Publisher

ieee

Conference_Titel

Nuclear Science Symposium Conference Record, 2003 IEEE

ISSN

1082-3654

Print_ISBN

0-7803-8257-9

Type

conf

DOI

10.1109/NSSMIC.2003.1352478

Filename

1352478