Fluid Resuscitation: Computer Simulation and Animal Experiments

The purpose of this study was to investigate the hemodynamic system in hemorrhagic shock and to estimate the effects of different infusion fluids and rates on the recovery of the bleeding patient. A mathematical model of the hemodynamic system was developed including fluid transfer to and from the interstitium for different types of fluids. The model was used to test different hemorrhagic shock conditions and different infusion conditions. To validate the model, a series of animal experiments was performed. The computer simulation followed successfully experimental data collected in five different experiments. Thus, it may now serve as an advanced tool for evaluating and analyzing effects of different fluids and optimize fluid regimen.