Quantitative analysis method to evaluate optical clearing effect of skin using a hyperosmotic chemical agent

Author

Jinhee Yoon ; Taeyoon Son ; Byungjo Jung

fYear

2007

fDate

22-26 Aug. 2007

Firstpage

3347

Lastpage

3349

Abstract

Light penetration depth in highly scattering tissues can be increased by using hyperosmotic chemical agents such as glycerol, PEG (polyethylene glycol) and glucose. Previous many studies used OCT, spectrometer, integrating method to quantitatively evaluate the optical clearing effect of skin. In this study, we show the optical clearing effect of skin using glycerol and suggest a new quantitative analysis method to evaluate the spatial optical clearing effect of skin using glycerol.

Keywords

biomedical optical imaging; optical tomography; organic compounds; patient diagnosis; skin; OCT; glucose; glycerol; highly scattering tissues; hyperosmotic chemical agent; integrating method; light penetration depth; optical clearing effect; polyethylene glycol; quantitative analysis; skin; spectrometer; Adaptive optics; Biomedical imaging; Biomedical optical imaging; Chemical analysis; Optical filters; Optical imaging; Optical microscopy; Optical scattering; Polarization; Skin; Algorithms; Animals; Dermoscopy; Image Interpretation, Computer-Assisted; Photosensitizing Agents; Refractometry; Reproducibility of Results; Sensitivity and Specificity; Skin Physiological Phenomena; Swine; Water-Electrolyte Balance;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE

Conference_Location

Lyon

ISSN

1557-170X

Print_ISBN

978-1-4244-0787-3

Type

conf

DOI

10.1109/IEMBS.2007.4353047

Filename

4353047