System-on-chip ultrasonic transducer for dental tissue formation and stem cell growth and differentiation

Conventional ultrasound designs are used for medical therapeutics including different tissue healing and medical imaging. Recently, we discovered that the low intensity pulsed ultrasound (LIPUS) can help stimulate dental and bone tissue growth. However, the size of available ultrasound devices is too large to fit inside the mouth.,. In this paper, we present the design of a system-on-chip ultrasonic device for dental tissue formation and stem cell growth differentiation. The device helps tissue healing by stimulating formation of new blood vessels and different tissue matrix formation, like bone, dentin and cementum. Testing results show that our prototype device can stimulate stem cells to grow and differentiate into bone forming cells.