Title :
Pharmacological fMRI - Challenges in Analysing Drug-Induced Single-Event BOLD Responses
Author :
Pohlmann, A. ; Barjat, H. ; Tilling, L.C. ; James, M.F.
Author_Institution :
GlaxoSmithKline R&D Ltd., Harlow
Abstract :
The interest in BOLD contrast based phMRI is likely to increase in the coming years, but detecting a direct modulation of regional brain activity by drugs presents a challenging problem. Based on in-vivo MRI and simulations we highlight some of the issues in detecting especially small BOLD signals in rat phMRI experiments.
Keywords :
biomedical MRI; brain; drugs; medical signal detection; drug-induced single-event BOLD responses; pharmacological fMRI; regional brain activity; signal detection; Analytical models; Animals; Biomedical monitoring; Brain modeling; Drugs; Image analysis; Magnetic resonance imaging; Rats; Stability; Surgery; Algorithms; Animals; Brain; Brain Mapping; Computer Simulation; Image Enhancement; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Male; Models, Neurological; Oxygen; Pharmaceutical Preparations; Rats; Reproducibility of Results; Sensitivity and Specificity;
Conference_Titel :
Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE
Conference_Location :
Lyon
Print_ISBN :
978-1-4244-0787-3
DOI :
10.1109/IEMBS.2007.4353064
