Title :
Lymph compartment models and HIV intra patient infection dynamics
Author :
Knorn, Steffi ; Middleton, R.H.
Author_Institution :
Signals & Syst. Group, Uppsala Univ., Uppsala, Sweden
Abstract :
A compartment model is proposed to describe the HIV infection in humans. The compartments describe the blood, several lymph nodes and connecting lymph vessels. The dynamics in each compartment are described by a simplified HIV model considering the healthy and infected T-cells. A bifurcation analysis based on the variation of the proliferation rate is discussed and supported by simulations. Additional simulations illustrate the effect of a simple mutation model.
Keywords :
bifurcation; blood; blood vessels; cellular biophysics; diseases; HIV intrapatient infection dynamics; HIV model; bifurcation analysis; blood; connecting lymph vessels; healthy T-cells; infected T-cells; lymph compartment models; lymph nodes; mutation model; proliferation rate variation; Analytical models; Bifurcation; Blood; Human immunodeficiency virus; Lymph nodes; Mathematical model;
Conference_Titel :
Control Applications (CCA), 2014 IEEE Conference on
Conference_Location :
Juan Les Antibes
DOI :
10.1109/CCA.2014.6981557
