Title :
A high-output-impedance current microstimulator for anatomical rewiring of cortical circuitry
Author :
Azin, Meysam ; Mohseni, Pedram
Author_Institution :
Electr. Eng. & Comput. Sci. Dept., Case Western Reserve Univ., Cleveland, OH
Abstract :
This paper reports on the design, implementation, and performance characterization of a high-output-impedance current microstimulator fabricated using the TSMC 0.35 mum 2P/4M n-well CMOS process as part of a fully integrated neural implant for reshaping long-range intracortical connectivity patterns in an injured brain. It can deliver a maximum current of 94.5 muA to the target cortical tissue with current efficiency of 86% and voltage compliance of 4.7 V with a 5-V power supply. The stimulus current can be programmed via a 6-bit DAC with an accuracy better than 0.47 LSB. Stimulator functionality is also verified with in vitro experiments in saline using a silicon microelectrode with iridium oxide (IrO) stimulation sites.
Keywords :
CMOS integrated circuits; bioMEMS; digital-analogue conversion; prosthetics; DAC; TSMC; anatomical rewiring; cortical circuitry; cortical tissue; fully integrated neural implant; high-output-impedance current microstimulator; injured brain; iridium oxide stimulation; n-well CMOS process; saline; silicon microelectrode; CMOS process; Circuits; Impedance; Implants; Injuries; Nerve fibers; Power supplies; Proteins; Silicon; Voltage;
Conference_Titel :
Circuits and Systems, 2008. ISCAS 2008. IEEE International Symposium on
Conference_Location :
Seattle, WA
Print_ISBN :
978-1-4244-1683-7
Electronic_ISBN :
978-1-4244-1684-4
DOI :
10.1109/ISCAS.2008.4541964
