Model single ion channel for structure investigation

This project presents a method to model a single channel from protein sequences provided by common protein sequences databanks. Under single-cell level, concrete protein structures will provide a configuration to simulate structural mechanics. Here a potassium was modeled, voltage-gated channel (Kv channel), to investigate its corresponding mechanics of each subunit. In electrophysiology, the potassium channel is defined as slow delayed rectifier potassium current (I_ks) by LRd ventricular cell model which defined completely in 2005. It is constructed from the conformational shape of the Shaker Kv1.2 channel as a template to model single KCNQ1 channel (Kv7.1).