Demonstration of implantable CMOS image sensors for functional brain imaging

Author

Sasagawa, Kiyotaka ; Sunaga, Yoshinori ; Haruta, Makito ; Yamaguchi, Toru ; Takehara, Hironari ; Takehara, Hironari ; Noda, Toshio ; Tokuda, Takashi ; Ohta, Jun

Author_Institution

Grad. Sch. of Mater. Sci., Nara Inst. of Sci. & Technol., Ikoma, Japan

fYear

2014

fDate

22-24 Oct. 2014

Firstpage

184

Lastpage

184

Abstract

We have developed implantable complementary -metal-oxide-semiconductor (CMOS) imaging devices for brain functional imaging (Fig.1) [1]. With the device, it is possible to perform fluorescence or absorption imaging and observe various neural activities of the mouse brain in a freely moving state [2, 3]. The device comprises a CMOS image sensor, and LEDs as excitation or illumination light sources. The pixel array is coated with absorption filter for excitation light rejection in the case of fluorescence imaging. It is expected that brain imaging in a freely moving mouse will be possible to elucidate relations between neural activities and behaviors.

Keywords

CMOS image sensors; biomedical optical imaging; brain; fluorescence; light emitting diodes; light sources; neurophysiology; prosthetics; LED; absorption filter; absorption imaging; brain functional imaging; excitation light rejection; excitation light sources; fluorescence imaging; freely moving mouse; freely moving state; functional brain imaging; illumination light sources; implantable CMOS image sensor; implantable complementary-metal-oxide-semiconductor imaging devices; mouse brain; neural activities; neural behaviors; pixel array; CMOS integrated circuits; Mice;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Circuits and Systems Conference (BioCAS), 2014 IEEE

Conference_Location

Lausanne

Type

conf

DOI

10.1109/BioCAS.2014.6981687

Filename

6981687