Title :
Semi-Automated Clustering of Gene Expression Data Sets
Author :
Minho Kim ; Ho-Youl Jung ; Myungguen Chung ; Pora Kim ; Seon-Hee Park ; Soo-Jun Park
Author_Institution :
Electron. & Telecommun. Res. Inst. (ETRI), Daejeon
Abstract :
Clustering, as one of key analysis tools for gene expression data sets, attempts to discover groups of genes having similar expression patterns. In order to get a reasonable biological interpretation, it is desirable that a clustering result be accurate enough. However, conventional clustering methods do not always meet this demand since they require the exact tuning of input parameters and cluster centers for an acceptable quality of result. Through an intuitive user interaction, Ul-Cluster solves the problem mentioned above, and yields better clustering results.
Keywords :
arrays; biology computing; genetics; pattern clustering; statistical analysis; Ul-Cluster; gene expression data sets; gene groups discovery; intuitive user interaction; microarray technology; semiautomated clustering; Binary trees; Bioinformatics; Clustering methods; Couplings; Data analysis; Euclidean distance; Gene expression; Image generation; Pattern analysis; Topology; Animals; Cluster Analysis; Computer Simulation; Gene Expression Profiling; Gene Expression Regulation; Humans; Oligonucleotide Array Sequence Analysis; Sensitivity and Specificity; Software;
Conference_Titel :
Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE
Conference_Location :
Lyon
Print_ISBN :
978-1-4244-0787-3
DOI :
10.1109/IEMBS.2007.4353370