A 12-channel dual-lock-in platform for magneto-resistive DNA detection with ppm resolution

Author

Gervasoni, G. ; Carminati, M. ; Ferrari, G. ; Sampietro, M. ; Albisetti, E. ; Petti, D. ; Sharma, P. ; Bertacco, R.

Author_Institution

Dipt. di Elettron., Politec. di Milano, Milan, Italy

fYear

2014

fDate

22-24 Oct. 2014

Firstpage

316

Lastpage

319

Abstract

Although lock-in detection is a well consolidated sensing technique, state-of-the-art commercial lock-in amplifiers do not allow reaching ppm resolution on long time scales due to low-frequency noise. We present a custom, multichannel platform that provides 0.7 ppm resolution, dedicated to pathogen DNA detection by means of Magnetic Tunnel Junction magneto-resistive sensors. A double modulation architecture (magnetic and electrical) is implemented in the FPGA that represents the core of the embedded digital processing unit.

Keywords

DNA; biochemistry; chemical sensors; field programmable gate arrays; lab-on-a-chip; magnetic sensors; magnetic tunnelling; magnetoresistance; molecular biophysics; noise; FPGA; double modulation architecture; embedded digital processing unit; lock-in amplifiers; low-frequency noise; magnetic tunnel junction magneto-resistive sensors; magneto-resistive DNA detection; multichannel platform; ppm resolution; twelve-channel dual-lock-in platform; DNA; Instruments; Magnetic sensors; Magnetic separation; Magnetic tunneling; Modulation; DNA detection; lab-on-a-chip; lock-in amplifier; magneto-resistance; ppm resolution;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Circuits and Systems Conference (BioCAS), 2014 IEEE

Conference_Location

Lausanne

Type

conf

DOI

10.1109/BioCAS.2014.6981726

Filename

6981726