Design of transdermal drug delivery system with PZT actuated micropump

Author

Dolzan, T. ; Vrtacnik, D. ; Resnik, D. ; Aljancic, U. ; Mozek, M. ; Pecar, B. ; Amon, S.

Author_Institution

Lab. of Microsensor Struct. & Electron., Univ. of Ljubljana, Ljubljana, Slovenia

fYear

2014

fDate

26-30 May 2014

Firstpage

96

Lastpage

99

Abstract

Investigation of transdermal drug delivery system, based on silicon injector chip with silicon microneedles and PZT (lead zirconate titanate) actuated micropump, for drug delivery such as insulin is reported. First, basic skin properties and dosing requirements are reviewed. Next, the whole system and its components (injector chip, micropump, drug container) are discussed. Based on this, microneedles injector chip design is discussed and prototypes fabricated. Then, design of PZT actuated micropumps is discussed and prototypes fabricated. From measurements on fabricated micropumps, fluidic parameters are evaluated. Basic requirements for drug container, control electronics and power supply parameters are also presented. Finally, maximum drug delivery, based on measured prototype micropump parameters, through the prototype injector chip is determined.

Keywords

drug delivery systems; elemental semiconductors; lead compounds; microactuators; microfluidics; micropumps; needles; power supply circuits; silicon; PZT; PZT actuated micropump; Si; control electronics; dosing requirements; drug container; fluidic parameters; injector chip design; insulin; lead zirconate titanate; power supply parameters; silicon injector chip; silicon microneedles; skin properties; transdermal drug delivery system; Containers; Drug delivery; Drugs; Micropumps; Needles; Prototypes; Skin;

fLanguage

English

Publisher

ieee

Conference_Titel

Information and Communication Technology, Electronics and Microelectronics (MIPRO), 2014 37th International Convention on

Conference_Location

Opatija

Print_ISBN

978-953-233-081-6

Type

conf

DOI

10.1109/MIPRO.2014.6859540

Filename

6859540