Biomedical microdevice for analyzing the effect of electrochemotherapy on cancer cells

A microfabricated cell-based testing device for electrochemotherapy (ECT) which mimics a clinical electroporator of circular needle-array has been developed while keeping the similarity of electric field strength distribution. Until now, the performances between the electroporators of two- and six-needle circular array electrodes, which are general needle-type clinical electroporators for ECT, have not been evaluated systemically although these two configurations are the two basic invasive electrodes in ECT. In this study, the cell-based performances of two-types of electroporators were analyzed by using propidium iodide and bleomycin on the developed ECT testing device and their electroporaion characteristics were exploited.