A 64-Channel ASIC for In-Vitro Simultaneous Recording and Stimulation of Neurons using Microelectrode Arrays

Author

Billoint, O. ; Rostaing, J.P. ; Charvet, G. ; Yvert, B.

Author_Institution

CEA LETI MINATEC, Grenoble

fYear

2007

fDate

22-26 Aug. 2007

Firstpage

6069

Lastpage

6072

Abstract

A 64 channels CMOS chip dedicated to in-vitro simultaneous recording and stimulation of neurons using microelectrode arrays has been developed. It includes, for each channel, a low noise, variable gain (10, 75 or 750), 0.08 Hz-3 kHz bandwidth measurement path with unity-gain for lower frequencies to allow measurement of the electrochemical potential. A snapshot style Sample & Hold circuitry allows to have "images" of the 64 channels at a maximum sampling frequency of 50 kHz. Input-referred noise of the measurement path is 4.3 muV RMS integrated from 0.08 Hz to 3 kHz. To get rid of the random, slowly varying, DC offset potential that exists at the electrode-electrolyte interface, the ASIC can be supplied with floating VSS, VDD. Circuit size is 2.4 mm per 11.2 mm (0.35 mum CMOS process) and its power consumption is about 125 mW.

Keywords

CMOS integrated circuits; application specific integrated circuits; bioelectric potentials; biomedical electrodes; biomedical electronics; biomedical measurement; electrochemical electrodes; microelectrodes; neurophysiology; sample and hold circuits; 64-channel ASIC; CMOS chip; DC offset potential; bandwidth 0.08 Hz to 3 kHz; electrochemical potential measurement; electrode-electrolyte interface; in-vitro simultaneous recording; input-referred noise; microelectrode array; neuron stimulation; sample-hold circuit; size 0.35 mum; size 2.4 mm; Application specific integrated circuits; Circuit noise; Frequency measurement; Gain measurement; In vitro; Integrated circuit measurements; Microelectrodes; Neurons; Noise measurement; Semiconductor device measurement; Action Potentials; Amplifiers, Electronic; Cells, Cultured; Electric Stimulation; Equipment Design; Equipment Failure Analysis; Humans; Microelectrodes; Neurons; Semiconductors; Signal Processing, Computer-Assisted;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE

Conference_Location

Lyon

ISSN

1557-170X

Print_ISBN

978-1-4244-0787-3

Type

conf

DOI

10.1109/IEMBS.2007.4353733

Filename

4353733