Title :
Optical recordings of cardiac transmembrane potential around an extracellular electrode in electrically anisotropic, bullfrog atrium
Author :
Neunlist, Michel ; Tung, Leslie
Author_Institution :
Lab. Pautrier, Inst. Nat. de la Sante et de la Recherche Med., Strasbourg, France
Abstract :
The authors have studied the spatial distribution of cardiac transmembrane potential around an extracellular unipolar electrode during electrical stimulation. The recordings were obtained from the bullfrog atrium along the transverse and longitudinal fiber directions. These recordings revealed the presence of a uniformly polarized region in the transverse fiber direction. In the longitudinal fiber direction, adjacent oppositely polarized regions coexist. These results are qualitatively predicted by an activation function developed for uncoupled fibers. They contradict the predictions of conventional cable models and also support newly developed models of cardiac tissue
Keywords :
biomembranes; cellular biophysics; electrocardiography; activation function; cardiac electrical stimulation; cardiac tissue models; cardiac transmembrane potential; conventional cable models predictions; electrically anisotropic bullfrog atrium; extracellular unipolar electrode; longitudinal fiber direction; optical recordings; transverse fiber direction; uncoupled fibers; uniformly polarized region; Anodes; Biomedical electrodes; Biomedical optical imaging; Cardiac tissue; Cathodes; Electrical stimulation; Electrodes; Extracellular; Optical fiber cables; Optical fiber polarization; Optical fibers; Optical recording; Power cables; Predictive models;
Conference_Titel :
Engineering in Medicine and Biology Society, 1994. Engineering Advances: New Opportunities for Biomedical Engineers. Proceedings of the 16th Annual International Conference of the IEEE
Conference_Location :
Baltimore, MD
Print_ISBN :
0-7803-2050-6
DOI :
10.1109/IEMBS.1994.412113
